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Publications

  • Wang JM, Seok SH, Yoon WS, Kim JH*, and Seo MD* (2023) Crystal structure of the engineered endolysin mtEC340M. Acta Cryst. F79, 105–110

  • Kim HN, Park HJ, Lin Y, Cho T, Ryu KS, Won HS, Jin HE, Kim JH, Baek SH*, Lee YH*, Seo MD* (2023) Coiled-coil structure mediated inhibition of the cytotoxic huntingtin amyloid fibrils by an IP3 receptor fragment. Int. J. Biol. Macromol. 232, 123412.

  • Sim YH, Um YJ, Park JY, Seo MD, Park SG (2022) A Novel Antibody-Drug Conjugate Targeting Nectin-2 Suppresses Ovarian Cancer Progression in Mouse Xenograft Models. Int. J. Mol. Sci. 23(20), 12358.

  • Yoo HS, Seok SH, Kim HN, Kim JH*, Seo MD* (2022) Molecular interaction between SH3 domain of PACSIN2 and proline-rich motifs of Cobll1. J. Kor. Mag. Res. Soc. 26, 34-39.

  • Park K, Yoo HS, Oh CK, Lee JR, Chung HJ, Kim HN, Kim SH, Kee KM, Kim TY, Kim M, Kim BG, Ra JS, Myung K, Kim H, Han SH*, Seo MD*, Lee Y*, Kim DW* (2022) Reciprocal interactions among Cobll1, PACSIN2, and SH3BP1 regulate drug resistance in chronic myeloid leukemia. Cancer Med. 11(21), 4005-4020.

  • Kim KH, Kim JO, Park JY, Seo MD, Park SG (2022) Antibody-Drug Conjugate Targeting c-Kit for the Treatment of Small Cell Lung Cancer. Int. J. Mol. Sci. 23(4), 2264.

  • Kim SR, Jeong MS, Mun SH, Cho J, Seo MD, Kim H, Lee J, Song JH, Ko HJ. (2021) Antiviral Activity of Chrysin against Influenza Virus Replication via Inhibition of Autophagy. Viruses 13(7), 1350.

  • Son SH, Do JM, Yoo JN, Lee HW, Kim NK, Yoo HS, Gee MS, Kim JH, Seong JH, Inn KS, Seo MD*, Lee JK*, Kim NJ* (2021) Identification of ortho catechol-containing isoflavone as a privileged scaffold that directly prevents the aggregation of both amyloid β plaques and tau-mediated neurofibrillary tangles and its in vivo evaluation. Bioorg. Chem. 113, 105022.

  • Seo MD, Seok SH, Kim JH, Choi JW, Park SJ, Lee BJ (2021) Molecular Interactions between Two LMP2A PY Motifs of EBV and WW Domains of E3 Ubiquitin Ligase AIP4. Life (Basel) 11(5), 379.

  • Park HJ, Kim HN, Kim CY, Seo MD*, Baek SH* (2021) Synergistic Protection by Isoquercitrin and Quercetin against Glutamate-Induced Oxidative Cell Death in HT22 Cells via Activating Nrf2 and HO-1 Signaling Pathway: Neuroprotective Principles and Mechanisms of Dendropanax morbifera Leaves. Antioxidants (Basel) 10(4), 554.

  • Park HJ, Jang J, Ryu KS, Lee J, Lee SH, Won HS, Kim EH, Seo MD*, Kim JH* (2021) Structural Interplays in the Flexible N-Terminus and Scaffolding Domain of Human Membrane Protein Caveolin 3. Membranes (Basel) 11(2), 82.

  • Seo MD (2020) Backbone NMR Assignments of WW2 domain from human AIP4 J. Kor. Mag. Res. Soc. 24, 1-5.

  • Seo MD (2020) Monitoring fibrillation of the pathogenic huntingtin protein using NMR J. Kor. Mag. Res. Soc. 24, 6-9.

  • Kim JO, Kim HN, Kim KH, Baek EJ, Park JY, Ha K, Her DR,  Seo MD* , and Park SG* (2020) Development and characterization of a fully human antibody targeting SCF/c-kit signaling. Int. J. Biol. Macromol. 159, 66-78.

  • Jo KS, Kim JH, Ryu KS, Kang JS, Wang CY, Lee YS, Seo MD, Lee YH, and Won HS (2019) Unique Unfoldase/Aggregase Activity of a Molecular Chaperone Hsp33 in its Holding-Inactive State. J. Mol. Biol. 431, 1468-1480.

  • Yoon WS, Seok SH, Won HS, Cho T, Lee SJ, and Seo MD (2019) Structural changes of antitoxin HigA from Shigella flexneri by binding of its cognate toxin HigB. Int. J. Biol. Macromol. 130, 99-108.

  • Sim DW, Song J, Kim JH, Lee JK, Chung DY, Jo KS, Kim CG, Seo MD, Kang HC, Paeng JC, Kim YP, and Won HS (2018) Enhancing bacterial production of a recombinant cetuximab-Fab by partial humanization and its utility for drug conjugation. Process Biochemistry 69, 123-130.

  • Kim JH, Won HS, Yoon WS, Seok SH, Jung BJ, Lee SN, Sim DW, and Seo MD* (2018) Crystal structure of shigella flexneri SF173 reveals a dimeric helical bundle conformation. Crystals 8, 97.

  • Kim HN, Seok SH, Lee YS, Won HS, and Seo MD* (2017) Crystal structure and functional characterization of SF216 from Shigella flexneri. FEBS Lett. 591,3692-3703.

  • Sim DW, Lu Z, Won HS, Lee SN, Seo MD, Lee BJ, and Kim JH (2017) Application of Solution NMR to Structural Studies on α-Helical Integral Membrane Proteins. Molecules 22(8). pii: E1347.

  • Sim DW, Choi JW, Kim JH, Ryu KS, Kim M, Yu HW, Jo KS, Kim EH, Seo MD, Jeon YH, Lee BJ, Kim YP, and Won HS (2017) C-terminal dimerization of apo-cyclic AMP receptor protein validated in solution. FEBS Lett. 591(7), 1064-1070.

  • Kim J, Seok SH, Hong E, Yoo TH, Seo MD*, and Ryu Y* (2017) Crystal structure and characterization of esterase Est25 mutants reveal improved enantioselectivity toward (S)-ketoprofen ethyl ester. Appl. Microbiol. Biotechnol. 101(6), 2333-2342.

  • Kim JH, Sim DW, Park D, Jung TG, Lee S, Oh T, Ha JR, Seok SH, Seo MD, Kang HC, Kim YP, and Won HS (2016) Bacterial production and structure-functional validation of a recombinant antigen-binding fragment (Fab) of an anti-cancer therapeutic antibody targeting epidermal growth factor receptor. Appl. Microbiol. Biotechnol. 100(24):10521-10529.

  • Lee SJ, Lee IG, Lee KY, Kim DG, Eun HJ, Yoon HJ, Chae S, Song SH, Kang SO, Seo MD, Kim HS, Park SJ, and Lee BJ (2016) Two distinct mechanisms of transcriptional regulation by the redox sensor YodB. Proc. Natl. Acad. Sci. USA 113(35), E5202-11.

  • Lee SY, Yoo HS, Choi HS, Chung KY*, and Seo MD* (2016) Structural and dynamic insights into the subtype-specific IP3-binding mechanism of the IP3 receptor. Biochem. J. 473(20), 3533-3543.

  • Lee KY, Choi HS, Cho HS, Chung KY, Lee BJ, Maeng HJ*, and Seo MD* (2016) Quercetin directly interacts with vitamin D receptor (VDR): Structural implication of VDR activation by quercetin. Biomol. Ther. 24(2), 191-198.

  • Park JY, Lee SY, Kim HR, Seo MD, and Chung KY (2016) Structural mechanism of GPCR-arrestin interaction: recent breakthroughs. Arch. Pharm. Res. 39(3), 293-301.

  • Chae YJ, Cho KH, Yoon IS, Noh CK, Lee HJ, Park Y, Ji E, Seo MD*, and Maeng HJ* (2016) Vitamin D receptor-mediated upregulation of CYP3A4 and MDR1 by quercetin in Caco-2 cells. Planta Medica 82(1-02),121-30.

  • Lee YS, Kim JH, Seo MD, Ryu KS, Kim EH, and Won HS (2015) Oxidation-induced conformational change of Hsp33, monitored by NMR. J. Kor. Mag. Res. Soc. 19, 99-105.

  • Kim YI, Song JH, Kwon BE, Kim HN, Seo MD, Park K, Lee S, Yeo SG, Kweon MN, Ko HJ, and Chang SY (2015) Pros and cons of VP1-specific maternal IgG for the protection of Enterovirus 71 infection. Vaccine 33(48), 6604-6610.

  • Lee YS, Lee J, Ryu KS, Lee Y, Jung TG, Jang JH, Sim DW, Kim EH, Seo MD, Lee KW, and Won HS (2015) Semi-Empirical Structure Determination of Escherichia coli Hsp33 and Identification of Dynamic Regulatory Elements for the Activation Process. J. Mol. Biol. 427(24), 3850-3861.

  • Lee YS, Yoon WS, Chung I, Chung KY, Won HS, and Seo MD* (2015) Backbone NMR Assignments of an Uncharacterized Protein, SF1002 from Shigella flexneri 5a M90T. J. Kor. Mag. Res. Soc. 19, 36-41.

  • Kim DK, Yun Y, Kim HR, Seo MD, and Chung KY (2015) Different conformational dynamics of various active states of β-arrestin1 analyzed by hydrogen/deuterium exchange mass spectrometry. J. Struct. Biol. 190(2), 250-259.

  • Park JY, Duc NM, Kim DK, Lee SY, Li S, Seo MD, Woods VL, and Chung KY (2015) Different conformational dynamics of PDZ1 and PDZ2 in full-length EBP50 analyzed by hydrogen/deuterium exchange mass spectrometry. Biochem. Cell Biol. 93(4), 290-297.

  • Choi HJ, Seok SH, Kim YJ, Seo MD, and Kim YS (2015) Crystal structures of immunoglobulin Fc heterodimers reveal the molecular basis for heterodimer formation. Mol. Immunol. 65(2), 377-383.

  • Yun Y, Kim DK, Seo MD, Kim KM, and Chung KY (2015) Different conformational dynamics of β-arrestin1 and β-arrestin2 analyzed by hydrogen/deuterium exchange mass spectrometry. Biochem. Biophys. Res. Commun. 457(1):50-57.

  • Kim HN, Seok SH, Chung KY, Son WS, and Seo MD* (2015) Expression, purification and structural characterization of the type 1-specific ATP binding site of IP3 receptor (IP3R1-ATPA). Process Biochemistry 50, 1600-1606.

  • Seo MD, Enomoto M, Ishiyama N, Stathopulos PB, and Ikura M (2015) Structural insights into endoplasmic reticulum stored calcium regulation by inositol 1,4,5-trisphosphate and ryanodine receptors. BBA-Mol. Cell. Res. 1853, 1980-1991.

  • Kim HN, An JG, Lee YS, Seok SH, Yoo HS, and Seo MD* (2015) Overexpression, purification, crystallization and preliminary X-ray crystallographic analysis of SF173 from Shigella flexneri. Acta Crystallogr. F Struct. Biol. Commun. 71(Pt 1), 54-56.

  • Seok SH, Im H, Won HS, Seo MD, Lee YS, Yoon HJ, Cha MJ, Park JY, and Lee BJ (2014) Structures of inactive CRP species reveal the atomic details of the allosteric transition that discriminates cyclic nucleotide second messengers.. Acta Crystallogr. D Biol. Crystallogr. 70, 1726-1742 .

  • Li C*, Enomoto M*, Rossi AM*, Seo MD*, Rahman T, Stathopulos PB, Taylor CW, Ikura M, and Ames JB (2013) CaBP1, a neuronal Ca2+ sensor protein, inhibits inositol trisphosphate receptors by clamping intersubunit interactions. Proc. Natl. Acad. Sci. USA 110(21), 8507-8512 (* : equal contribution).

  • Stathopulos PB*, Seo MD*, Enomoto M *, Amador FJ*, Ishiyama N*, and Ikura M (2012) Themes and Variations in ER/SR Calcium Release Channels: Structure and Function. Physiology 27(6), 331-342 (* : equal contribution).

  • Seo MD, Won HS, Kim JH, Mishig-Ochir T, and Lee BJ (2012) Antimicrobial peptides for therapeutic applications: a review. Molecules 17(10), 12276-12286.

  • Seo MD, Kang TJ, Lee CH, Lee AY, and Noh M (2012) HaCaT Keratinocytes and Primary Epidermal Keratinocytes Have Different Transcriptional Profiles of Cornified Envelope-Associated Genes to T Helper Cell Cytokines. Biomol. Ther. 20(2), 171-176.

  • Seo MD*, Velamakanni S*, Ishiyama N, Stathopulos PB, Rossi AM, Khan SA, Dale P, Li C, Ames JB, Ikura M, and Taylor CW (2012) Structural and functional conservation of key domains in InsP3 and ryanodine receptors. Nature 483, 108-112.

  • Chan J, Yamazaki H, Ishiyama N, Seo MD, Mal TK, Michikawa T, Mikoshiba K, and Ikura M (2010) Structural studies of inositol 1,4,5-trisphosphate receptor: coupling ligand binding to channel gating. J. Biol. Chem. 285(46), 36092-36099.

  • Sim DW, Lee YS, Kim JH, Seo MD, Lee BJ, and Won HS (2009) HP0902 from Helicobacter pylori is a thermostable, dimeric protein belonging to an all-beta topology of the cupin superfamily. BMB Rep. 42(6), 387-392.

  • Seo MD*, Seok SH*, Im H, Kwon AR, Lee SJ, Kim HR, Cho Y, Park D, and Lee BJ (2009) Crystal structure of the dimerization domain of human filamin A. Proteins 75(1), 258-263.

  • Park SJ, Seo MD, Lee SK, and Lee BJ (2008) Membrane binding properties of EBV gp110 C-terminal domain; evidences for structural transition in the membrane environment. Virology. 379(2), 181-190.

  • Won HS, Seo MD, Ko HS, Choi WS, and Lee BJ (2008) Thermal denaturation of apo-cyclic AMP receptor protein and noncovalent interaction between domains. Mol. Cells 26(1), 61-66.

  • Park SJ, Jung YS, Kim JS, Seo MD, and Lee BJ (2008) Structural insight into the distinct properties of copper transport by the Helicobacter pylori CopP protein. Proteins 71(2), 1007-1019.

  • Won HS, Seo MD, Ko HS, Choi WS, and Lee BJ (2008) Interdomain interaction of cyclic AMP receptor protein in the absence of cyclic AMP. J. Biochem. 143, 163-167.

  • Seo MD, Park SJ, Kim HJ, Seok SH, and Lee BJ (2007) Backbone 1H, 15N, and 13C resonance assignment and secondary structure prediction of HP0495 from Helicobacter pylori. J. Biochem. Mol. Biol. 40, 839-843.

  • Seo MD, Park SJ, Kim HJ, and Lee BJ (2007) Solution Structure of hypothetical protein, HP0495 (Y495_HELPY) from Helicobacter pylori. Proteins 67, 1189-1192.

  • Seo MD, Park SJ, Kim HJ, and Lee BJ (2007) Identification of the WW domain-interaction sites in the unstructured N-terminal domain of EBV LMP 2A. FEBS Lett. 581, 65-70.

  • Seo MD, Won HS, Oh U, and Lee BJ (2007) Structural study of the C-terminus of Vanilloid Receptor 1. J. Kor. Magn. Reson. 11, 85-94.

  • Won HS*, Seo MD*, Jung SJ, Lee SJ, Kang SJ, Son WS, Kim HJ, Park TK,  Park SJ, and Lee BJ (2006) Structural determinants for the membrane interaction of novel bioactive undecapeptides derived from gaegurin 5. J. Med. Chem. 49, 4886-4895.

  • Do EH, Jo EB, Choi G, Piao LZ, Shin J, Seo MD, Kang SJ, Lee BJ, Kim KH, Kim JB, and Kim SI (2006) Melanocortin 4 receptors interact with antimicrobial frog peptide analogues. Biochem. Biophys. Res. Commun. 343, 1094-1100.

  • Park SJ, Seo MD, Lee SK, Ikeda M, Longnecker R, Lee BJ (2005) Expression and characterization of N-terminal domain of Epstein-Barr virus latent membrane protein 2A in Escherichia coli.  Protein Expr. Purif. 41, 9-17.

  • Won HS, Jung SJ, Kim HE, Seo MD, and Lee BJ (2004) Systematic peptide engineering and structural characterization to search for the shortest antimicrobial peptide analogue of gaegurin 5. J. Biol. Chem. 279, 14784-14791

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